The Guardian's novels everyone must read: SF and fantasy
I was thinking this Guardian article could make a good meme (bold the books on this list you've read, etc), but now that I actually know which books are included in the list, I'm not sure it'll catch on. It's essentially a litsnob attempt at a canon of great SF and fantasy, part of the Guardian's 1000 books you must read series. What's interesting about it, though, is that it rejects the usual litsnob approach of saying "this book is of literary merit and therefore cannot be labeled anything as lowbrow and worthless as science fiction" and instead opts for a widely inclusive approach, putting Mikhail Bulgakov and Larry Niven in the same list.  Anyway, here's the list, and I've bolded the ones I've read.

Douglas Adams: The Hitchhiker's Guide to the Galaxy (1979)
Brian W Aldiss: Non-Stop (1958)
Isaac Asimov: Foundation (1951)
Margaret Atwood: The Blind Assassin (2000)
Paul Auster: In the Country of Last Things (1987)
Iain Banks: The Wasp Factory (1984)
Iain M Banks: Consider Phlebas (1987)
Clive Barker: Weaveworld (1987)
Nicola Barker: Darkmans (2007)
Stephen Baxter: The Time Ships (1995)
Greg Bear: Darwin's Radio (1999)
Alfred Bester: The Stars My Destination (1956)
Poppy Z Brite: Lost Souls (1992)
Algis Budrys: Rogue Moon (1960)
Mikhail Bulgakov: The Master and Margarita (1966)
Edward Bulwer-Lytton: The Coming Race (1871)
Anthony Burgess: A Clockwork Orange (1960)
Anthony Burgess: The End of the World News (1982)
Edgar Rice Burroughs: A Princess of Mars (1912)
William Burroughs: Naked Lunch (1959)
Octavia Butler: Kindred (1979)
Samuel Butler: Erewhon (1872)
Italo Calvino: The Baron in the Trees (1957)
Ramsey Campbell: The Influence (1988)
Lewis Carroll: Alice's Adventures in Wonderland (1865)
Lewis Carroll: Through the Looking-Glass, and What Alice Found There (1871)
Angela Carter: Nights at the Circus (1984)
Michael Chabon: The Amazing Adventures of Kavalier and Clay (2000) (have it, haven't read it yet)
Arthur C Clarke: Childhood's End (1953)
GK Chesterton: The Man Who Was Thursday (1908)
Susanna Clarke: Jonathan Strange and Mr Norrell (2004)
Michael G Coney: Hello Summer, Goodbye (1975)
Douglas Coupland: Girlfriend in a Coma (1998)
Mark Danielewski: House of Leaves (2000)
Marie Darrieussecq: Pig Tales (1996)
Samuel R Delany: The Einstein Intersection (1967)
Philip K Dick: Do Androids Dream of Electric Sheep? (1968)
Philip K Dick: The Man in the High Castle (1962)
Umberto Eco: Foucault's Pendulum (1988)
Michel Faber: Under the Skin (2000)
John Fowles: The Magus (1966)
Neil Gaiman: American Gods (2001) (have it, haven't read it yet)
Alan Garner: Red Shift (1973)
William Gibson: Neuromancer (1984)
Charlotte Perkins Gilman: Herland (1915)
William Golding: Lord of the Flies (1954)
Joe Haldeman: The Forever War (1974)
M John Harrison: Light (2002) (have it, haven't read it yet)
Robert A Heinlein: Stranger in a Strange Land (1961)
Frank Herbert: Dune (1965)
Hermann Hesse: The Glass Bead Game (1943)
Russell Hoban: Riddley Walker (1980)
James Hogg: The Private Memoirs and Confessions of a Justified Sinner (1824)
Michel Houellebecq: Atomised (1998)
Aldous Huxley: Brave New World (1932)
Kazuo Ishiguro: The Unconsoled (1995)
Shirley Jackson: The Haunting of Hill House (1959) (don't own it, but I'm pretty sure I read it in school)
Henry James: The Turn of the Screw (1898)
PD James: The Children of Men (1992)
Richard Jefferies: After London; Or, Wild England (1885)
Gwyneth Jones: Bold as Love (2001)
Franz Kafka: The Trial (1925)
Daniel Keyes: Flowers for Algernon (1966)
Stephen King: The Shining (1977)
Marghanita Laski: The Victorian Chaise-longue (1953)
Joseph Sheridan Le Fanu: Uncle Silas (1864)
Stanislaw Lem: Solaris (1961)
Doris Lessing: Memoirs of a Survivor (1974)
David Lindsay: A Voyage to Arcturus (1920)
Ken MacLeod: The Night Sessions (2008)
Hilary Mantel: Beyond Black (2005)
Michael Marshall Smith: Only Forward (1994) (have it, haven't read it yet)
Richard Matheson: I Am Legend (1954)
Charles Maturin: Melmoth the Wanderer (1820)
Patrick McCabe: The Butcher Boy (1992)
Cormac McCarthy: The Road (2006)
Jed Mercurio: Ascent (2007)
China Miéville: The Scar (2002)
Andrew Miller: Ingenious Pain (1997)
Walter M Miller Jr: A Canticle for Leibowitz (1960)
David Mitchell: Cloud Atlas (2004)  (have it, haven't read it yet; Laura's read it, I'm not sure I'll bother)
Michael Moorcock: Mother London (1988)
William Morris: News From Nowhere (1890)
Toni Morrison: Beloved (1987)
Haruki Murakami: The Wind-up Bird Chronicle (1995)
Vladimir Nabokov: Ada or Ardor (1969)
Audrey Niffenegger: The Time Traveler's Wife (2003)
Larry Niven: Ringworld (1970)
Jeff Noon: Vurt (1993)
Flann O'Brien: The Third Policeman (1967)
Ben Okri: The Famished Road (1991)
Chuck Palahniuk: Fight Club (1996)
Thomas Love Peacock: Nightmare Abbey (1818)
Mervyn Peake: Titus Groan (1946)
John Cowper Powys: A Glastonbury Romance (1932)
Christopher Priest: The Prestige (1995)
François Rabelais: Gargantua and Pantagruel (1532-34)
Ann Radcliffe: The Mysteries of Udolpho (1794)
Alastair Reynolds: Revelation Space (2000)
Kim Stanley Robinson: The Years of Rice and Salt (2002)
JK Rowling: Harry Potter and the Philosopher's Stone (1997)
Salman Rushdie: The Satanic Verses (1988)
Antoine de Sainte-Exupéry: The Little Prince (1943)
José Saramago: Blindness (1995)
Will Self: How the Dead Live (2000)
Mary Shelley: Frankenstein (1818)
Dan Simmons: Hyperion (1989)
Olaf Stapledon: Star Maker (1937)
Neal Stephenson: Snow Crash (1992)
Robert Louis Stevenson: The Strange Case of Doctor Jekyll and Mr Hyde (1886) (have it, haven't read it yet)
Bram Stoker: Dracula (1897)
Rupert Thomson: The Insult (1996)
Mark Twain: A Connecticut Yankee at King Arthur's Court (1889)
Kurt Vonnegut: Sirens of Titan (1959)
Robert Walser: Institute Benjamenta (1909)
Sylvia Townsend Warner: Lolly Willowes (1926)
Sarah Waters: Affinity (1999)  (have it, haven't read it yet; Laura's read it)
HG Wells: The Time Machine (1895)
HG Wells: The War of the Worlds (1898)
TH White: The Sword in the Stone (1938)
Gene Wolfe: The Book of the New Sun (1980-83)
John Wyndham: Day of the Triffids (1951)
John Wyndham: The Midwich Cuckoos (1957)
Yevgeny Zamyatin: We (1924)

There are a lot of writers in the list for whom I could say, well, I haven't read that one, but I've read several others by him or her, but I don't suppose that really counts...